Sensitivity, Specificity, and False Negative rate by Indication for Examination for 401,548 Diagnostic Mammography Examinations from 2007 - 2013
Based on BCSC data through 2013
| Work-Up of Abnormal Screening Exams | Short-Interval Follow-Up | Evaluation of Breast Problem/ No Lump or Lump Unknown | Evaluation of Breast Problem/ Palpable Lump | All Diagnostic Exams** | |
|---|---|---|---|---|---|
| Sensitivity* | 91.8% | 60.8% | 83.6% | 92.3% | 87.8% |
| True positives† | 5,909 | 525 | 1,853 | 2,279 | 13,915 |
| Cancers‡ | 6,435 | 863 | 2,217 | 2,470 | 15,841 |
| Specificity§ | 86.9% | 95.8% | 93.0% | 86.8% | 90.5% |
| True negatives|| | 106,509 | 48,430 | 67,121 | 28,502 | 348,963 |
| Non-Cancers# | 122,541 | 50,577 | 72,209 | 32,838 | 385,707 |
| False negative rate (per 1000)†† | 4.1 | 6.6 | 4.9 | 5.4 | 4.8 |
| False negatives‡‡ | 526 | 338 | 364 | 191 | 1,926 |
| All examinations | 128,976 | 51,440 | 74,426 | 35,308 | 401,548 |
Notes:
Numbers are frequencies unless otherwise indicated.
The first non-zero assessment within 90 days was used as the final assessment for analysis.
** Includes 94,228 exams from one registry for which sub-classification of diagnostic indication (e.g., additional evaluation, short interval follow-up, etc.) was not available.
* Sensitivity = the percentage of cancers that had an abnormal final interpretation
(BI-RADS category 4 or 5; Note: 0 or 3 with a recommendation for biopsy was recoded as 4).
† True Positive = the number of cancers that had an abnormal final interpretation
(BI-RADS category 4 or 5; Note: 0 or 3 with a recommendation for biopsy was recoded as 4).
‡ Cancers = the number of examinations with a tissue diagnosis of cancer within 1 year following the examination.
§ Specificity = the percentage of non-cancers that had a negative final interpretation
(BI-RADS category 1, 2, or 3; Note: 0 with no recommendation for biopsy nor additional imaging/workup was recoded as 3,
while 3 with a recommendation for biopsy was recoded as 4).
|| True Negative = the number of non-cancers that had a negative final interpretation
(BI-RADS category 1, 2, or 3; Note: 0 with no recommendation for biopsy nor additional imaging/workup was recoded as 3,
while 3 with a recommendation for biopsy was recoded as 4).
# Non-cancers = the number of examinations without a tissue diagnosis of cancer within 1 year following the examination.
†† False negative rate = the rate (per 1000 exams) of false-negative exams.
‡‡ False negatives = the number of cancers that had a negative final interpretation.
Table numbers last updated Mar 26, 2017.
The following must be cited when reproducing this data:
"The Breast Cancer Surveillance Consortium and its data collection and sharing activities are funded by the National Cancer Institute (P01CA154292). Downloaded xx/xx/xxxx from the Breast Cancer Surveillance Consortium Web site - http://www.bcsc-research.org/."