Diagnostic Mammography Sensitivity, Specificity, & False Negative Rate

Sensitivity, Specificity, and False Negative rate by Indication for Examination for 401,548 Diagnostic Mammography Examinations from 2007 - 2013

Based on BCSC data through 2013

  Work-Up of Abnormal Screening Exams Short-Interval Follow-Up Evaluation of Breast Problem/ No Lump or Lump Unknown Evaluation of Breast Problem/ Palpable Lump All Diagnostic Exams**
Sensitivity* 91.8%      60.8%     83.6%       92.3%         87.8%  
True positives 5,909 525 1,853 2,279 13,915
Cancers 6,435 863 2,217 2,470 15,841
Specificity§ 86.9% 95.8% 93.0% 86.8% 90.5%
True negatives|| 106,509 48,430 67,121 28,502 348,963
Non-Cancers# 122,541 50,577 72,209 32,838 385,707
False negative rate (per 1000)†† 4.1 6.6 4.9 5.4 4.8
False negatives‡‡ 526 338 364 191 1,926
All examinations 128,976 51,440 74,426 35,308 401,548
Notes:
Numbers are frequencies unless otherwise indicated.
The first non-zero assessment within 90 days was used as the final assessment for analysis.
**  Includes 94,228 exams from one registry for which sub-classification of diagnostic indication (e.g., additional evaluation, short interval follow-up, etc.) was not available.
*  Sensitivity = the percentage of cancers that had an abnormal final interpretation
(BI-RADS category 4 or 5; Note: 0 or 3 with a recommendation for biopsy was recoded as 4).
 True Positive = the number of cancers that had an abnormal final interpretation
(BI-RADS category 4 or 5; Note: 0 or 3 with a recommendation for biopsy was recoded as 4).
 Cancers = the number of examinations with a tissue diagnosis of cancer within 1 year following the examination.
§  Specificity = the percentage of non-cancers that had a negative final interpretation
(BI-RADS category 1, 2, or 3; Note: 0 with no recommendation for biopsy nor additional imaging/workup was recoded as 3,
while 3 with a recommendation for biopsy was recoded as 4).
||  True Negative = the number of non-cancers that had a negative final interpretation
(BI-RADS category 1, 2, or 3; Note: 0 with no recommendation for biopsy nor additional imaging/workup was recoded as 3,
while 3 with a recommendation for biopsy was recoded as 4).
#  Non-cancers = the number of examinations without a tissue diagnosis of cancer within 1 year following the examination.
††  False negative rate = the rate (per 1000 exams) of false-negative exams.
‡‡  False negatives = the number of cancers that had a negative final interpretation.
Table numbers last updated Mar 26, 2017.

The following must be cited when reproducing this data:

"The Breast Cancer Surveillance Consortium and its data collection and sharing activities are funded by grants from the National Cancer Institute (P01CA154292, U54CA163303), Patient-Centered Outcomes Research Institute (PCS-1504-30370), and Agency for Health Research and Quality (R01 HS018366-01A1). Downloaded xx/xx/xxxx from the Breast Cancer Surveillance Consortium Web site - http://www.bcsc-research.org/. More information regarding the BCSC is available at: http://bcsc-research.org/."